Can a hybrid web app be built?

A hybrid web app meaning a coldbox mvc app + none mvc app.

Would like to buld an app that loads the user details based on their
username, e.g. while at the same time being able
to access different none mvc apps like:

How will the system know when a user profile is being requested, or
when an application is being requested based on the url?

If needed, you may ask for clarification.

Thank you for your contributions!