RE: RE: RE: [coldbox:9172] Very slow startup and errors on startup.

Thanks for reporting back on that. Since CF can generate thousands of class files that makes sense that it could really slow down on an encrypted drive.
Since CF also stores the templates in memory, you shouldn’t notice any impact until you restart your server and it has to start over again and recompile everything. I would bump up your “Maximum number of cached templates” setting to ensure you don’t surpass it since you turned off disk caching.