Trouble with Helicon Isapi Rewrite

Has anybody gottent isapi rewrite to work on iis and coldbox where it
does not throw errors for invalid event handlers.main???

Are there any rules that need to be changed from normal Apache?

We have Ionics ISAPI rewrite filters (http://www.codeplex.com/IIRF) on IIS6 on one of our projects and it works as expected. (CB 2.6.x)