I’m getting this error intermittently on a production server that is only running 4 applications (2 coldbox, 2 Mango blogs). I don’t expect the cache to be full. The PF usage is running at 75% of actual RAM.

Framework Initialization/Configuration Exception
Error Type: Framework.InterceptorService.InterceptorCantBeCached : [N/A]
Error Messages: The interceptor could not be cached, either the cache is full, the threshold has been reached or we are out of memory.

Look at the cache settings of the application. Look for the JVMThresholdPercentage.

That should be set to a lower level, set it to 0 as it makes the JVM handle itself.